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Recently, Wangs team discovered that the promoter region of GPX4 binds to cyclic adenosine monophosphate response element binding protein (CREB) and that this binding can be enhanced by E1A binding protein P300 (EP300), promoting tumor proliferation, migration, invasion and angiogenesis

Cisplatin is a commonly used drug for treating osteosarcoma, but osteosarcoma cells can develop resistance to it, which reduces its therapeutic effect (190)