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Safety Profile and Considerations General Safety Pure Glutathione Powder has an excellent safety profile: *Glutathione is an endogenous molecule produced naturally in every cell of the human body - the body is intimately familiar with its metabolism *Clinical trials using oral glutathione at doses up to 1,000 mg/day for 6 months have reported no significant adverse events *The Thyroid meta-analysis of selenium (which works through the glutathione system) confirmed that adverse effects were comparable between intervention and control groups (OR 0.89) across 1,339 participants *No serious drug interactions have been documented at supplemental doses Possible Side Effects (Rare) *Mild GI discomfort (bloating, loose stools) - rare

Trace elements in human nutrition (II) - an update

Animals in the LOsG and sham groups ( n = 10 in both groups) were given 6 g/kg glucose and distilled water (2 mL/100 g body weight), respectively, by gavage every 6 h for 6 weeks

Broekhuizen LN, Lemkes BA, Mooij HL, Meuwese MC, Verberne H, Holleman F, Schlingemann RO, Nieuwdorp M, Stroes ES, Vink H