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High-sensitivity variants suggest you may experience more pronounced initial side effects, including dizziness, allowing your prescriber to use a slower titration schedule or lower starting dose to minimize symptoms

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and Jin et al., showed that high concentrations of HNE (30-200 M) increased NLRP3 mRNA expression, IL-1, and IL-18 secretion in human ARPE-19 cells after LPS stimulation (60, 61)