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This effect was shown to depend on the v-ATPase (Ruckenstuhl et al., 2014), which is coupled to yeast TOR activation (Saliba et al., 2018)

Next, the Western diet, characterized by high consumption of red meat, processed foods, and high-fat, high-sugar content with insufficient fiber, promotes dysbiosis and an increase in pro-inflammatory bacteria

54 Additionally, metabolic syndrome is a risk factor for chronic kidney disease (CKD) that is at least in part independent of diabetes and hypertension and probably mediated by ROS