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At day 3, the media was replaced with culture media supplemented with insulin (10 g/ml)

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[44] Pentosan Polysulfate Sodium Peptide (Elmiron) and AOD 9604 decrease pain receptors in the brain, which reduces the subjective perception of pain

Acta Haematologica 145:244256 Cutrona G, Tripodo C, Matis S, Recchia AG, Massucco C, Fabbi M, Colombo M, Emionite L, Sangaletti S, Gulino A, Reverberi D (2018) Microenvironmental regulation of the IL-23R/IL-23 axis overrides chronic lymphocytic leukemia indolence