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Moreover, Th1 and Th17 suppression, decreased macrophage activation, and compromised fungal clearance were linked to the formation of immunomodulatory DCs in a mouse model of chronic C

Pain Modulation: DSIP is hypothesized to have analgesic-like properties, possibly by influencing opioid receptor activity and modulating pain signal transmission pathways

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Likewise, thiazolidinediones (e.g., pioglitazone) used in some PCOS settings may reduce oxidative stress, adipocytederived inflammatory signaling, and neutrophil activation thresholds (though direct NETosis data are limited)