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384,385 Additionally, GWAS has identified several novel genetic loci associated with DPN, underscoring the complex genetic architecture underlying this condition

For example, in certain neurodegenerative diseases, modulating SIRT3 activity can help manage mitochondrial dysfunction and oxidative stress 182

In this article, the authors reported that this plant contains two important compounds, carnosic acid and phenolic diterpene, and both showed promising activities on the selective isoforms of KCNQ (Manville et al., 2023)

Elevated levels of ROS and iron in haematopoietic cells lacking the H-ferritin gene lead to a reduction in T-cell populations ( Figure 2 ) (112)