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Rebrin I, Sohal RS (2008) Pro-oxidant shift in glutathione redox state during aging

Despite being in its nascent stages for AD treatment and encountering numerous challenges, such as poor biocompatibility, inadequate penetration of deep brain tissue by NIR light, and cumulative toxicity risks, PTT remains a promising therapeutic strategy to overcome the limitations of AD treatment

These findings demonstrate that STING palmitoylation is a potent pharmacological target for inhibiting STING signaling and thus for the treatment of STING-dependent inflammatory diseases

Notably, CRISPR/Cas9-mediated GPX4 knockout experiments demonstrated that selenomethionine retains its anti-ferroptosis activity in GPX4-deficient cells, suggesting the existence of GPX4-independent mechanisms