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Evidence supporting the involvement of activated microglia-mediated chronic neuroinflammation in PD includes: (1) Pro-inflammatory effects are often observed in activated microglia surrounding dopaminergic neurons, with the degree of microglial activation correlating with dopaminergic endings loss in PD (174, 175)

Later, a mobster's fedora lands on Bugs' head, which causes him to talk and act like a mobster, including smoking an accompanying cigar, whose smoke he blows in Elmer's face while threatening to "rub [him] out"