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Storage: Store at 20C in a dry, dark environment protected from light, heat, and moisture

During disease progression, the accumulation of aberrant proteins can overwhelm the cellular chaperone system, as the demand for refolding and clearance exceeds its capacity 97

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Selective inhibition of a single pathway can often trigger compensatory activation of alternative signaling pathways, ultimately decreasing therapeutic efficacy [245,246,247,248,249,250]