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Several occupational carcinogens are associated with lung cancer, including: Asbestos Arsenic Diesel exhaust Silica dust Chromium compounds Nickel compounds Certain mining exposures Risk may be especially high when occupational exposure occurs together with smoking

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At a subcellular level, toxins in cigarette smoke, such as cadmium and acrolein, are known to induce mitochondrial dysfunction and increase oxidative stress

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