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All three compounds displayed 40% cytotoxicity at the highest concentration tested (P 0.001, 600 M-treated cells vs

APOE4 expression increases unsaturated triglyceride-rich lipid droplet formation in astrocytic endoplasmic reticulum (ER), impairing lipid droplet clearance and heightening sensitivity to lipid peroxidation, thereby elevating AD risk (Windham et al., 2024)

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b , Proportion of cells expressing the BFP reporter present in the gRNA plasmid at the initial time point (0 weeks) and late time point (3 weeks)