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Thats where peptides come into the conversation

The animals lost body weight and fat mass, had smaller adipocytes, and showed lower cholesterol, and notably did it with no change in food intake

Your doctor may: Test your ability to feel different sensations on your feet and legs, such as dull or sharp pinpricks Test your reflexes by tapping the tendon under your knee with a reflex hammer Check for your pulse in your feet Test your leg strength by having you push or pull against their hands or arms Together, the results of these tests help your doctor determine what is causing your leg cramps

doi:10.1016/S0196-9781(03)00194-3 164