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These findings suggest that AS-IV exerts synergistic neuroprotective effects at the multicellular level by simultaneously targeting the JNK apoptotic pathway and the NLRP3 inflammatory pathway ( Another study demonstrated that atractylenolide-I (ATR-I), the primary active component of Atractylodes macrocephala Koidz., exhibits significant neuroprotective effects in PD models

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Diabetes Obes Metab 4:2935 El Midaoui A, de Champlain J (2002) Prevention of hypertension, insulin resistance, and oxidative stress by alpha-lipoic acid

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