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9396 NNK appears to preferentially induce lung tumors in the rat, regardless of the route of administration, and DNAnitrosamine adducts are detectable in lung tissues

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As a reactive a,b-unsaturated aldehyde, acrolein can exacerbate dyslipidemia that can lead to accelerated atherosclerosis, modify A-I protein in high-density lipoprotein (HDL) [33, 34] and catalytic neutrophil-mediated inflammation [35], and enhance platelet activation which contributes to an increased risk of thrombosis in animal models [36]