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As proof of concept that endosomal maturation inhibitors have clinical potential, CQ and hydroxy-CQ (HCQ), lysosomotropic agents that block endosomal acidification, are used to treat SLE 49 , RA 50 and, to a lesser extent, sJIA 51

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176 Some other noncoding RNAs and their potential downstream targets were identified and proposed in the heart in response to exercise training, such as miR-1 and miR-214 (targeting NCX and SERCA2a), 177 miR-27a/b and miR-143 (targeting angiotensin-converting enzyme-Angiotensin II genes), 178 miR-208a/b (targeting Med13, Pur, Sox6, HP1, and SP3), and miR-21, miR-144, miR-145, miR-124 (targeting PI3K/AKT signaling)

10.3389/fimmu.2023.1051606 111 XiaY.YangR.WangH.HouY.LiY.ZhuJ.et al (2022a)