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Improving the tumor uptake of 99mTc-labeled neuropeptides using stabilized peptide analogues

This lack of significant improvement may be attributed to the activation of VEGF-independent angiogenic pathways, the recruitment of proangiogenic stromal cells, the induction of vasculogenesis or even the dose of the antiangiogenic agent used, which may reduce the size of blood vessel pores, further obstructing the delivery of this antibody [30, 39, 40]

For prevention in people with normal absorption, oral cyanocobalamin suffices

Besides the main differential characteristics, other negative findings to rule out common causes of true TMA, such as TTP, HUS, DIC, drug-induced TMA, autoimmune-associated TMA, etc., are also essential to guide primary specific management