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After one-third of the study participants have been enrolled and completed follow-up, the DSMBs will review the data and make recommendations concerning continuation, modification or termination of the study due to unexpectedly large beneficial effects or serious side effects and can suggest extension of the trial should the primary outcomes occur less often than anticipated

This gene-regulatory capacity appears to be central to its observed effects, effectively recalibrating cellular activity towards a state of regeneration and homeostasis

Repressing the storage of additional glycogen and fat deposits

Patients on prolonged INH therapy often receive supplemental pyridoxine to prevent peripheral neuropathy, an adverse effect related to B deficiency