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Serum alanine amino transferase (ALT) levels, lipid peroxidation, hepatic glutathione (GSH) contents, and liver histopathological changes were assessed in different conditions after methimazole administration alone and/or in combination with NAC

In most cases it is not permanent damage

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183,184 The non-lytic mechanism of NET formation involves an increase in cytoplasmic calcium concentration activating protein arginine deiminase 4 (PAD4), which results in the citrullination of arginine residues on histones and reduction of the positive charge