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These results clearly suggest that the treatment with MMP-3 stimulates the expression of Rac1b, which increases intracellular ROS, leading to the induction of EMT, suggesting that MMP-3 inhibitor or the inhibitors of ROS could be useful in the reversal of EMT or the killing of EMT-type cells or cancer stem cells leading to decreased tumor aggressiveness (Figure 4)

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Antibody selection The desired antibody may be selected from a larger set of two or more candidate antibodies based on affinity and/or specificity for the target antigen and/or an epitope thereof