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Future trials should also measure important outcomes such as the clinical signs and symptoms of vitamin B 12 deficiency, health related-quality of life, socioeconomic effects, and report adverse events adequately, preferably in a primary care setting. Clinical practice guidelines British Columbia Medical Services Commission (MSC)

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The epidemiological data presented in Table 1 sheds light on the prevalence of DPN and painful DPN, and the percentage of undiagnosed DPN and painful DPN among these patients [5, 8, 24,25,26,27,28,29,30,31,32]

Many patients achieve their target weight loss at 5 mg or 10 mg and remain there as their maintenance dose