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Pharmacology Biochemistry and Behavior, 133 , 1-6

CJC-1295/Ipamorelin is different because it targets the mechanism that shifts first in the female body after 35: growth hormone pulse frequency, regulated by estrogen, begins declining before a woman notices fatigue, stubborn weight gain, or slow recovery

What it does not justify is casual, unsupervised use of a compound whose long-term human safety profile is still being written

This caution comes mainly from cosmetic formulators rather than from dermatology trials, and the evidence is limited, so it is not something to state as a hard rule