vitamin c-induced decomposition of lipid hydroperoxides to endogenous genotoxins Structures hydroperoxide-derived bifunctional electrophiles Vitamin C physiology: the known

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Upon ligand binding, TR II phosphorylates and activates TR I, forming a heteromeric receptor complex that initiates downstream signaling through both SMAD-dependent and SMAD-independent pathways, such as ERK, p38, JNK, and PI3K-Akt cascades [33, 36, 39]

However, this approach cannot distinguish specific forms of reversible Oxi-Cys, as all reversible Oxi-Cys residues are labeled and analyzed