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In 2008, in a study including data from 160 children with UTI or CAKUT, we proved that, in those with a normal maximum urine osmolality, the GFR was always normal while all patients with a reduced GFR had an altered concentrating capacity.43 In that study, the GFR was calculated with the classic Schwartz formula that uses a constant value of 0.55, which now we recognize that it overestimates GFR

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doi: 10.1016/j.immuni.2010.12.009 48 TalbotJHahnPKroehlingLNguyenHLiDLittmanDR

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