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The clinical material is chemically synthesized, not biologically extracted

Preclinical studies confirm that combined treatment with HF and an EGFR-TKI exerts synergistic cytotoxicity compared with EGFR-TKI monotherapy, highlighting promising application prospects, especially in overcoming resistance to third-generation EGFR-TKIs (132)

Phosphoproteomic analysis of released and non-arrested human CD8 + T cells revealed clusters of phosphorylation sites linked to activated glycolysis, transcription factors, FOXK1 and FOXK2, which regulate glycolysis-related genes 29 , and activation of MAPKc-MYC and JAKSTAT signaling (Fig

The majority of current evidence results from preclinical studies, highlighting the critical necessity for carefully organised human clinical trials to validate its therapeutic advantages (Culpepper, 2022)