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Xia L, Tan S, Zhou Y, Lin J, Wang H, Oyang L, et al

Recent studies have shown that SIRT1 exerts a neuroprotective effect in MPP+-treated dopaminergic neurons, primarily through deacetylation of PKM2, which improves brain lactate homeostasis and upregulates PGC-1 expression, promoting mitochondrial biogenesis in MPP+-treated cells 8,41

2012;19:S539548

Consistent with the established role of activated microglia in synaptic pruning, our data demonstrated a significant increase in SYNAPTOPHYSIN1 + puncta within microglia and their lysosomes, indicating enhanced engulfment of presynaptic terminals and suggesting that microglial activity under these conditions may contribute specifically to presynaptic terminal loss [93]