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10.1200/JCO.2008.17.4839 15 ChoeyprasertW.SawangpanichR.LertsukprasertK.UdomsubpayakulU.SongdejD.UnurathapanU.et al

(Radad et al., 2015)

Cancer-related chronic pain and its management may lead to mental disorders, and depression and anxiety in particular can alter the synthesis of inflammatory cytokines and chemokines, the metabolism of neurotransmitters and the function of the neuroendocrine system (90)