melanoma melanotic Melanocytic nevi and malignant Nodular melanoma | Acral lentiginous

Roberson-Nay R, et al

Therefore, oxidative stress and microRNA regulatory networks may significantly impact neuronal processes leading to neurodegeneration, including mitochondrial defects, loss of proteostasis, and increased neuroinflammation among others

Moreover, overproduction of ROS has an impact to enhance the cancer cell proliferation, migration, metastasis, invasiveness and poor prognosis through many cellular mechanisms like matrix degradation, cell-cell contact, cell remodelling, as well as regulation of gene expression [54]

These methods require further RNA extraction from samples via complex, time-consuming processes, which can cause further degradation of the RNA, resulting in poor-quality RNA and reduced reproducibility of outcomes