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360 TGF- Crosstalk with PI3K, NF-B, HIF-1, MAPK, Wnt In addition to its interaction with BMPR2 signal transduction, TGF- can also interact with other signaling pathways (PI3K, NF-B, HIF-1, MAPK, and Wnt) to contribute to the EndMT, proliferation, and inflammation of PAECs, as well as promoting the proliferation of PASMCs and enhancing ECM remodeling of PAFs and RVFs (Fig

The ethanol extract of lonicera japonica (Japanese honeysuckle) attenuates diabetic nephropathy by inhibiting P-38 mapk activity in streptozotocin-induced diabetic rats