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The participation of the E3 ubiquitin ligase CHIP is also typically required (Ulbricht et al., 2013)

In this paper, we have provided a comprehensive description of the structure and function of Piezo1, a discussion of the pathophysiological role of Piezo1 channels in CNS diseases, and an examination of the pharmacological properties of Piezo1 channel antagonists or inhibitors as targeted therapies to reduce its expression in CNS diseases