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Retatrutides safety profile is consistent with whats already been observed GLP-1 receptor agonists and combined GLP-1/GIP receptor agonists, meaning the expected side effects are primarily gastrointestinal (GI) in nature: Nausea, vomiting, diarrhea, and constipation

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The gut produces these compounds in response to various signals, including the presence of beneficial bacteria, the integrity of the intestinal lining, and inflammatory status

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Therefore, neurogenesis has been proposed to facilitate stress resilience, which might be the foundation of antidepressant therapeutic benefits

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