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Interestingly, the reversal of the FXN gene silencing in neurons derived from patient iPSCs is comparable to that found in previous studies performed on PBMCs and in vivo models [55,56,57,58]

Detailed statistical values are provided in Supplementary Table 7

Interestingly, lower levels of branched-chain amino acids (BCAAs) and keto acids in the blood have been linked to the effect of tirzepatide and LAGIPRA on insulin sensitivity

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