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Pulmonary histologic analysis showed that LTF diminished pathological lesion development, including diffuse alveolar hemorrhage and hemosiderosis and accumulation of pulmonary edema, which were common in control lungs after injection of the eliciting dose of ovalbumin

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Taken together, evidence of early locus coeruleus pathology in AD and PD, reductions in norepinephrine transporters with aging, AD and PD, and robust norepinephrine transporter engagement by antidepressants point to the norepinephrine transporter as a critical, yet understudied target in LLD [169, 178]

Junctional adhesion molecules (JAM, ~40 kDa) are transmembrane molecules localized to apical cell-cell contacts and associated with TJs