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This was most recently shown by such studies as ASCEND (A Study of Cardiovascular Events in Diabetes) [71], STRENGTH (Long-Term Outcomes Study to Assess Statin Residual Risk with Epanova in High Cardiovascular Risk Patients with Hypertriglyceridemia) [72], OMEMI (Omega-3 fatty acids in Elderly with Myocardial Infarction) [73] and VITAL (Vitamin D and Omega-3 Trial) trials [74]

1 are reversible, class I glutaredoxins can also catalyze the GSSR- or GSSG-dependent glutathionylation of thiols or the formation of (protein) disulfides 3,5,35,61

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