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Due to its affordability and low toxicity profile, metformin is increasingly used to prevent or treat a wide range of gynecological disorders, as evidenced by epidemiological studies, clinical trials, and animal and in vitro studies

Sodium butyrate (NaB), a histone deacetylase inhibitor, increases NRF2 expression and alleviates oxidative stress and insulin resistance induced by a high-fat diet [80]

Research published in Biomolecules & Therapeutics demonstrates that curcumin directly inhibits Syk kinase, an enzyme critical for the activation cascade triggered when IgE antibodies bind to the mast cell surface