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We suggest that reduced GPx1 in monocytes recruited to the gut and intestinal macrophages renders these cells vulnerable to reactive oxygen species-evoked ferroptosis cell death and that unraveling the participation of this pathway in Crohns disease may reveal novel therapeutic approaches to this chronic condition

Compared with nonsteroidal anti-inflammatory drugs, this approach is particularly effective in patients with menstrual disorders associated with insufficient prostaglandin F2 secretion (Robeldo et al., 2020)