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Serving as a primary source of IPP, the mevalonate pathway is a crucial signaling network for GPX4 maturation and ferroptosis induction

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Physical health Frailty Frailty is a syndrome prevalent among geriatric populations and characterized by a functional decline and a loss of independence to perform the activities of daily living

In the MPTP mouse model, MPTP is metabolized to MPP + in glial cells and accumulates in dopaminergic neurons via the dopamine transporter, causing selective neurodegeneration and oxidative stress