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To enhance the clinical application of hydrogen therapy, it is essential to conduct more multicenter, large-sample, long-term follow-up studies, particularly to investigate its efficacy in patient populations at various stages of disease progression

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10.1111/j.1471-4159.2004.02520.x 13 CaoD.KevalaK.KimJ.MoonH

Although the molecular basis for the genetic association has not been explored in detail, it was suggested that APOE4 may directly bind to TREM2 and thus alter TREM2 signaling