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FIGURE 2 3.1 Mitochondrial metabolism and bioenergetics in gluco- and lipotoxicity Dysregulated mitochondrial bioenergetics, metabolism, and OXPHOS are frequently observed in models of T2D

GSH-degrading enzymes are essential for maintaining GSH homeostasis in cells

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In addition, accessory proteins such as COQ4, COQ8A/B, COQ9 and COQ10A/B are believed to facilitate enzyme complex assembly, substrate channeling or stabilization of the biosynthetic complex (commonly referred to as the CoQ synthome) but their precise molecular functions are still under investigation