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Mesnage R, Benbrook C, Antoniou MN

AlmuhayawiMSHassanAHAAbdel-MawgoudMKhamisGSelimSAl JaouniSKet al

To interrogate the mechanisms underlying NRF2-directed regulation of this core gene set, we compared mean promoter (1 kb restricted) ChIP-seq signal in A549 for NRF2, p300, as well as the histone marks H3K4me3 and H3K27ac, which are enriched at promoters and enhancers, respectively

At each timepoint, patients underwent blood analyses, including hematological, biochemical, inflammatory, and neuroaxonal impairment markers ( Table 3 )