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WB Saunders Company, Philadelphia

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Levine, M., Rumsey, S

What a COA (Certificate of Analysis) Should Include Identity Confirmation Mass spectrometry confirming the correct molecular weight (639.8 Da for SS-31) Amino acid sequence verification matching D-Arg-Dmt-Lys-Phe-NH2 Confirmation of the Dmt (2,6-dimethyltyrosine) residue the most critical modification Purity Testing HPLC purity look for 98%+ purity The chromatogram should show a single dominant peak with minimal truncated-sequence impurities Contamination Testing Endotoxin levels (bacterial contamination) Residual solvent analysis (acetonitrile, TFA) Heavy metals screening How to Verify a COA Is Legitimate Check the testing lab Reputable labs include Janoshik Analytical, MZ Biolabs, and Colmaric Analyticals