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Just like in humans, vitamin B-12 deficiency in animals is also conducive to weight gain

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According to the Mayo Clinic, if your vitamin deficiency is severe enough to make you feel lethargic, you could gain weight as a result of reducing your exercise and movement

With respect to dosage, the average reductions were: 2000 mcg: 71.5% (single data point) 1,000 mcg: 31.8% Although limited data are available for higher dosages, the findings support the efficacy of both oral and non-oral B12 formulations in modulating homocysteine levels