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As glutathione can improve the numbers and activity of macrophages, peptic ulcers may be exacerbated [40] Increased susceptibility to melanoma: Theoretically, long-term administration of systemic glutathione switches eumelanin to pheomelanin, and may increase the susceptibility towards development of melanoma in the long run

As it is well established that a leaky barrier characterized by increased tight junction permeability is a hallmark of pathological conditions including CRC, proteins involved in tight junction structure represent an effective target for the evaluation of gut barrier status

VK1 has been shown to prevent lipid peroxidation and acts as an effective endogenous antioxidant, particularly in acute kidney injury (Kolbrink et al., 2022a)

Inhaled glutathione is another method of administration, sometimes used in clinical settings, but it can cause respiratory side effects, especially in people with asthma