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Joffe E, Coombes KR, Qiu YH, Yoo SY, Zhang N, Bernstam EV, Kornblau SM

Biochem Pharmacol 86(9):13111319

The formation of adducts between these carcinogenic metabolites and DNA in bladder epithelial cells can lead to gene mutations and cellular transformations, significant mechanisms in the development of bladder cancer ( Figure 2 )