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Pol II phosphorylation regulates a switch between transcriptional and splicing condensates

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These practices not only increase the risk of ADRs but also intensify environmental selection pressure for resistant organisms, the combined effects of multiple pharmaceuticals (mixture toxicity) in the environment may produce synergistic or additive effects that are not predicted from single-compound assessments, representing a critical knowledge gapas noted by researchers such as Golding et al

Addressing these gaps will be essential to determine whether lipin-1 functions are intrinsically partitioned or instead dynamically integrated across macrophage states