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Similar associations have been reported in bipolar disorder and systemic lupus erythematosus, where individuals with severe BBB disruption had more extensive brain volume loss or greater psychiatric morbidity 50,51

This work is supported by the Natural Products & Nanobiotechnology Research Lab, Saveetha Institute of Basic Medical Sciences (SIBMS), Saveetha Institute of Medical and Technical Sciences (SIMATS), (Saveetha University), Thandalam, Chennai, Tamil Nadu 602105, India Conflict of interest The author declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest