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In parallel, a study in PCOS women with hyperhomocysteinemia found that 1 mg folic acid daily for 3 months effectively decreased Hcy levels in all participants, with a more significant diminution observed in non-IR women, implying that folic acid supplementation contributes to improving the bodys methylation status and mitigates associated vascular endothelial damage (66)

Likewise, increased 3-nitrotyrosine (3-NT) levels, a marker for peroxynitrite-mediated damage, were observed within spinal cord MNs [91]