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Left untreated, bunions can worsen, leading to greater discomfort and potential mobility issues

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GCH1 is the rate-limiting enzyme for BH4, and the GCH1/BH4 pathway can regulate redox reactions and cell apoptosis, thereby protecting cells from the impact of oxidative stress and mitochondrial damage (83, 84)

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This modulation is important in maintaining balance between matrix synthesis and degradation in research models

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