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The persistent effect on re-pigmentation of vitiligo after the injections of antioxidants and the increasing effect with a repeated course, support the theory of involvement of oxidative stress in the pathogenesis of vitiligo

When these isolated senescence cells were presented with FOXO4-DRI peptide, researchers reported that the peptide appeared to block FOXO4 proteins, allowing p53 to bind with DNA, which led to the nuclear exclusion of p53 and induction of apoptosis of the senescent Leydig cells