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The reduction of roGFP2(S 2 ) is therefore a good example for an enzyme using an alternative reaction pathway to overcome a kinetic challenge, and we hypothesize that other non-glutathione disulfide substrates with reactive proximal cysteinyl residues and rather negative redox potentials also require a ternary complex for their reduction

Pavesi A, Ficarelli A, Tassi F, Restivo FM

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Whatever the underlying cause of hyperinsulinemia, the result is a reduction in glucose uptake by the muscles and an increase in the production of liver glycogen, which aids in the progress of T2D [36], [85], [86,87,88,89]